Authors: Joanna Matyjasik Cezary Cybulski Bartlomiej Masojć Anna Jakubowska Pablo SerranoFernandez Bohdan Górski Tadeusz Dębniak Tomasz Huzarski Tomasz Byrski Jacek Gronwald Elzbieta Złowocka Steven Alexander Narod Rodney Scott Jan Lubinski
Publish Date: 2007/04/26
Volume: 106, Issue: 3, Pages: 383-388
Abstract
In combinations of the R48G A119S and L432V SNPs four of the eight CYP1B1 haplotypes were more common in controls than in cases and each of these appeared to have a significant protective effect A large reduction in risk was observed for women who were homozygous for one of these four haplotypes OR = 02 95 CI = 005–05 P = 0001 compared to women who were homozygous for the most common haplotype In contrast women who were homozygous for the GTC haplotype were at increased risk OR = 15 95 CI = 10–21 P = 003 compared to women with the most common haplotypeWe would like to acknowledge the contributions of M Bębenek J Bręborowicz M Chosia B Czeszyńska R Czajka B Dębniak W Domagała I Dziuba M FoszczyńskaKłoda LFudali S GozdeckaGrodecka S Góźdź E Grzybowska K Gugała O Haus H Janiszewska A Karczewska J Kładny R Kordek A Kozak B KozakKlonowska W Kozłowski KLamperska D Lange A Lenczewski A Mackiewicz E Marczyk BMąka T Mierzwa M Morawiec B Musiatowicz J Mituś S Niepsuj M Posmyk A Rozmiarek J Ryś J Sir J Skręt M Stawicka DSorokin JSygut CSzczylik M Szwiec D Surdyka M Uciński K Urbański P Wandzel BWaśko A Witek RWiśniowski A Wojnar J Woytoń O Zambrano in collection of patients and controls
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