Authors: Lidia Rosi Medeiros Célia Scapin Duarte Daniela Dornelles Rosa Maria Isabel Edelweiss Marcia Edelweiss Fábio Rosa Silva Erik Paul Winnnikow Patrícia Duarte Simões Pires Maria Inês Rosa
Publish Date: 2011/01/08
Volume: 126, Issue: 2, Pages: 273-285
Abstract
Dynamic contrastenhanced breast magnetic resonance MR is a promising emerging technique for evaluating breast lesions A quantitative systematic review was performed to estimate the accuracy of breast MR in the diagnosis of highrisk breast lesions and breast cancer A comprehensive search of the Cochrane Library MEDLINE CANCERLIT LILACS and EMBASE databases was performed from January 1985 to August 2010 The medical subjects heading MeSH and text words for the terms “breast neoplasm” “breast lesions” “breast cancer” and “magnetic resonance” were combined with the MeSH term diagnosis “sensitivity and specificity” Studies that compared breast MR with paraffinembedded sections parameters for the diagnosis of breast lesions benign highrisk borderline and breast cancer were included Sixtynine studies were analyzed which included 9298 women with 9884 breast lesions Interrater overall agreement between breast MR and paraffin section diagnosis was 79 κ = 055 indicating moderate agreement Pooled sensitivity and specificity were 90 95 CI 88–92 and 75 95 CI 70–79 respectively The pooled likelihood positive ratio was 364 95 CI 30–42 and the negative ratio was 012 95 CI 009–015 For breast cancer or highrisk lesions versus benign lesions the AUC was 091 for breast MR and the point Q was 084 In summary breast MR is a useful preoperative test for predicting the diagnosis of breast lesions
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