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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1016/0022-3999(85)90053-4

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ISSN

1573-7217

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The impact of oophorectomy on survival after breas

Authors: T Huzarski T Byrski J Gronwald C Cybulski O Oszurek M Szwiec K Gugała M Stawicka Z Morawiec T Mierzwa M Falco H Janiszewska E Kilar E Marczyk B KozakKlonowska M Siołek D Surdyka R Wiśniowski M Posmyk P Domagała P Sun J Lubiński S A Narod The Polish Breast Cancer Consortium
Publish Date: 2016/03/17
Volume: 156, Issue: 2, Pages: 371-378
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Abstract

The aim of the study is to identify treatments which predict survival for women with a BRCA1 mutation including oophorectomy and chemotherapy 476 women with stage I to stage III breast cancer who carried a BRCA1 mutation were followed from diagnosis until April 2015 Information on treatment was obtained from chart review and patient questionnaires Dates of death were obtained from the Poland vital statistics registry Survival curves were compared for different subgroups according to treatment received Predictors of overall survival were determined using the Cox proportional hazards model The tenyear overall survival was 783  95  CI 742–826  and the tenyear breast cancerspecific survival was 842  95  CI 805–880  Sixtytwo patients died of breast cancer 14 patients died of ovarian cancer and 2 patients died of peritoneal cancer Oophorectomy was associated with a significant reduction in allcause mortality in the entire cohort adjusted HR = 041 95  CI 024–069 p = 00008 and in breast cancerspecific mortality among ERnegative breast cancer patients HR = 044 95  CI 022–089 p = 002 Among women with breast cancer and a BRCA1 mutation survival is greatly improved by oophorectomy due to the prevention of deaths from both breast and ovarian cancerAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standardsBębenek M BłasińskaMorawiec M Breborowicz J Chosia M Drosik K Dziuba I Fudali L GozdeckaGrodecka S Goźdź S Grzybowska E Haus O Jeziorski A Karczewska A Kordek R Kozak A Kozłowski A Lamperska K Lange D Mackiewicz A J Menkiszak Mituś J Musiatowicz B Niepsuj S Rozmiarek A Ryś J Sibilski R Sir J Sorokin D Sygut J Szczylik C Uciński M Urbański K Wachuła E Waśko B Wojnar A Wandzel P

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