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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1007/bf03303772

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ISSN

1573-7217

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Variability in hormone and growth factor receptor

Authors: Mark N Jabbour Cleo Y Massad Fouad I Boulos
Publish Date: 2012/04/08
Volume: 135, Issue: 1, Pages: 29-37
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Abstract

The introduction of selective molecular targeted therapy specifically tamoxifen and trastuzumab has significantly altered the clinical behavior of breast carcinoma Several questions remain however regarding potential phenotypic drifts in estrogen receptor ER progesterone receptor PR and epidermal growth factor receptor Her2/neu expression between the primary and metastatic site Whether patients should be tested for ER PR and Her2/neu expression in the nodal or distant metastatic site local recurrence and following neoadjuvant therapy and whether this has an effect on prognosis remains elusive A review of 45 studies addressing ER PR and Her2/neu expression in lymph node metastasis distant metastasis local recurrence and postneoadjuvant therapy revealed the following average phenotypic drift in ER PR and Her2/neu expression respectively 131  median = 100  138  median = 160  and 77  median = 50  for lymph node metastasis 218  median = 195  308  median = 335  and 76  median = 61  for distant metastasis 198  median = 134  271  median = 286  and 66  median = 16  for local recurrence and 129  median = 80  320  median = 200  and 89  median = 0  postneoadjuvant therapy The above findings support the notion of reevaluating ER PR and Her2/neu expression in distant metastasis lymph node metastasis and to a lesser extent local recurrence The effects of neoadjuvant therapy on receptor expression are more pronounced for PR which may have a prognostic role in therapy efficacy

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