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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1002/ardp.19853180713

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ISSN

1573-7217

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Detection and prevalence of disseminated tumor cel

Authors: Andreas D Hartkopf FlorinAndrei Taran Christina B Walter Markus Hahn Tanja Fehm Markus Wallwiener Sara Y Brucker
Publish Date: 2015/05/27
Volume: 152, Issue: 1, Pages: 51-55
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Abstract

Male breast cancer mBC is a rare entity As detection of disseminated tumor cells DTCs in the bone marrow of females with early stage breast cancer is a promising prognostic marker we aimed to determine the prevalence and prognostic value of DTCs in mBC Bone marrow aspirates were collected from male patients undergoing primary surgery for early stage breast cancer T1–4 N0–2 M0 at Tuebingen University Germany between January 2001 and April 2015 DTCs were identified by immunocytochemistry pancytokeratin antibody A45/BB3 and cytomorphology 24 patients with mBC were included into the analysis DTCs were detected in four of these 17  There was no significant association between the DTC status and any other clinicopathological parameter Also no significant impact of the DTC status on DFS or OS could be observed DTCs are detectable in patients with early stage mBC The detection rate is comparable to that in women No associations between DTCs and clinicopathological features or prognosis were observed which is most likely due to the small sample size The detection of DTCs in male patients with early stage breast cancer emphasizes the transmission of future clinical applications for DTCs from women to men

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