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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Publisher

Springer US

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DOI

10.1016/0038-1101(68)90099-3

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ISSN

1573-7217

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Feature extraction via composite scoring and votin

Authors: Martin Koch Markus Hanl Michael Wiese
Publish Date: 2012/07/26
Volume: 135, Issue: 1, Pages: 307-318
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Abstract

Identification and characterization of tumor subtypes using gene expression profiles of triple negative breast cancer patients Microarray data of four breast cancer studies were pooled and evaluated Molecular subtype classification was performed using random forest and a novel algorithm for feature extraction via composite scoring and voting Biological and clinical properties were evaluated via GSEA functional annotation clustering and clinical endpoint analysis The subtype signatures are highly predictive for distant metastasis free survival of tamoxifentreated patients Consensus clustering and the novel algorithm proposed three triple negative subtypes One subtype shows low E2F4 gene expression and is predictive for survival of ER negative breast cancer patients The other two subtypes share commonalities with luminal B tumors Classification of breast cancer expression profiles may reveal novel tumor subtypes possessing clinical impact Furthermore subtype characterizing gene signatures might hold potential for novel strategies in cancer therapy

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  6. Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha
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  9. Diagnosis and management of primary breast sarcoma
  10. Recurrent read-through fusion transcripts in breast cancer
  11. Anastrozole versus tamoxifen as adjuvant therapy for Japanese postmenopausal patients with hormone-responsive breast cancer: efficacy results of long-term follow-up data from the N-SAS BC 03 trial
  12. Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
  13. Accuracy of magnetic resonance in suspicious breast lesions: a systematic quantitative review and meta-analysis
  14. The impact of oophorectomy on survival after breast cancer in BRCA1 -positive breast cancer patients
  15. Impact of carpal tunnel syndrome surgery on women with breast cancer-related lymphedema
  16. A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer
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