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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1007/bf02552662

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ISSN

1573-7217

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Genetic variants in trinucleotide repeatcontainin

Authors: Jie Liang Peizhan Chen Zhibin Hu Hao Shen Furu Wang Lu Chen Mian Li Jinhai Tang Hui Wang Hongbing Shen
Publish Date: 2010/03/09
Volume: 124, Issue: 1, Pages: 237-241
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Abstract

Trinucleotide repeatcontaining 9 TNRC9 a high mobility group chromatinassociated protein has been implicated in breast cancer metastasis to the bone Recently several single nucleotide polymorphisms SNPs of TNRC9 were identified as novel breast cancer susceptibility loci by whole genome association studies especially in estrogen receptor ER positive tumors In the present case–control study of 1049 breast cancer patients and 1073 cancerfree controls in a Chinese population we genotyped three polymorphisms rs3803662C/T rs12443621A/G and rs8051542C/T of the TNRC9 gene using the SNPstream 12plex platform to test the hypothesis that these SNPs are associated with breast cancer risk in this population None of the three polymorphisms was significantly associated with breast cancer risk in the whole data set P = 0151 0644 and 0737 for rs3803662 rs12443621 and rs8051542 respectively However rs12443621 AG/GG genotypes were significantly associated with increased risk of ER positive breast cancer OR = 138 95 CI = 101–188 compared with homozygote AA In addition a borderline significantly increased risk was also observed for the variant genotypes CT/TT of rs8051542 C/T compared with the wildtype genotype CC adjusted OR = 126 95 CI = 099–160 Interestingly a significant interaction was detected between rs12443621A/G and ER status on breast cancer risk in a caseonly analysis P for interaction = 0004 These findings suggest that genetic variants of TNRC9 may contribute to the development of ER positive breast cancerWe would like to thank our collaborators in the Department of General Surgery Jiangsu Cancer Hospital Jianwei Qin and in the Department of General Surgery The First Affiliated Hospital of Nanjing Medical University Shui Wang This study was supported in part by the Innovative Key Grant of Department of Education 705023 National Key Basic Research Program Grants 2002CB512908 Program for Changjiang Scholars and Innovative Research Team in University IRT0631 and by grants from 863 program 2007AA02Z474 from One Hundred Talents Program of the Chinese Academy of Sciences a grant from the National Nature Science Foundation 30870513 a grant 2007CB947100 from the Ministry of Science and Technology of China a grant 08391910800 from the Science and Technology Commission of Shanghai Municipality and the Food Safety Research Center and Key Laboratory of Nutrition and Metabolism

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