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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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ISSN

1573-7217

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Plasma S100P level as a novel prognostic marker of

Authors: Cike Peng Hongda Chen Markus Wallwiener Caroline Modugno Katarina Cuk Dharanija Madhavan Andreas Trumpp Jörg Heil Frederik Marmé Juliane Nees Sabine Riethdorf Sarah Schott Christof Sohn Klaus Pantel Andreas Schneeweiss Rongxi Yang Barbara Burwinkel
Publish Date: 2016/05/04
Volume: 157, Issue: 2, Pages: 329-338
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Abstract

Metastasis is the main cause of death in breast cancer patients The development of reliable and costeffective biomarker to evaluate the prognosis of metastatic breast cancer MBC patients is of great importance S100P is a member of S100 family and has been proved to be associated with metastasis establishment Methods We investigated the plasma S100P levels in 60 healthy controls 48 primary and 273 metastatic breast cancer patients The MBC patients were followedup for disease progression and death up to 35 years after recruitment Radiographic response of MBC patients were also analyzed for investigation on treatment monitoring value of plasma S100P level We found a robust association between high plasma S100P level 7 ng/mL and poor prognosis of metastatic breast cancer MBC patients median progressionfree survival time 50 vs 87 months logrank test p  0001 median overall survival time 225 vs 316 months logrank test p  0001 The plasma S100P level added additional prognostic relevance to the conventional prognostication model with clinicopathological factors and CTC enumeration The plasma S100P level decreased significantly after treatment while the reduction correlated with the radiographic response of the MBC patients This finding indicates the value of plasma S100P in dynamic evaluation of treatment outcome We hereby suggest plasma S100P level as a simple and costeffective marker for the prognosis of metastatic breast cancerThis study was funded and supported by the DietmarHopp Foundation the University Hospital of Heidelberg the Helmholtz Society the German Cancer Research Center DKFZ Heidelberg Germany and the National Center for Tumor Diseases Heidelberg Germany IFPProject I2 Cike Peng is funded by China Scholarship Council CSC for a 4year PhD program

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