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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1007/s10549-017-4143-6

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ISSN

1573-7217

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MR imaging features associated with distant metast

Authors: Sung Eun Song Sung Ui Shin HyeongGon Moon Han Suk Ryu Kwangsoo Kim Woo Kyung Moon
Publish Date: 2017/02/09
Volume: 162, Issue: 3, Pages: 559-569
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Abstract

Preoperative breast magnetic resonance MR imaging features of primary breast cancers may have the potential to act as prognostic biomarkers by providing morphologic and kinetic features representing inter or intratumor heterogeneity Recent radiogenomic studies reveal that several radiologistannotated image features are associated with genes or signal pathways involved in tumor progression treatment resistance and distant metastasis DM We investigate whether preoperative breast MR imaging features are associated with worse DMfree survival in patients with invasive breast cancerOf the 3536 patients with primary breast cancers who underwent preoperative MR imaging between 2003 and 2009 147 patients with DM were identified and onetoone matched with control patients n = 147 without DM according to clinical–pathologic variables Three radiologists independently reviewed the MR images of 294 patients and the association of DMfree survival with MR imaging and clinical–pathologic features was assessed using Cox proportional hazard modelsOf MR imaging features rim enhancement hazard ratio HR 183 95 confidence interval CI 129 251 p = 0001 and peritumoral edema HR 148 95 CI 103 211 p = 0032 were the significant features associated with worse DMfree survival The significant MR imaging features however were different between breast cancer subtypes and stagesPreoperative breast MR imaging features of rim enhancement and peritumoral edema may be used as prognostic biomarkers that help predict DM risk in patients with breast cancer thereby potentially enabling improved personalized treatment and monitoring strategies for individual patientsAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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