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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1016/0167-5273(83)90148-1

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1573-7217

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Using qualityadjusted progressionfree survival a

Authors: Vakaramoko Diaby Georges Adunlin Askal Ayalew Ali Rima Tawk
Publish Date: 2014/07/14
Volume: 146, Issue: 3, Pages: 669-673
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Abstract

The aim of this study is to estimate the qualityadjusted progressionfree survival QAPFS as an effectiveness measure for the treatment arms of the BOLERO2 trial For each treatment arm of the trial QAPFS was estimated by multiplying the overall health utility weights associated with progressionfree survival PFS accounting for utility decrements associated with the adverse events of treatments by the corresponding mean PFS time Health utility data were obtained from the literature while mean PFS times were estimated through a survival analysis of the reconstructed individual patient data of the BOLERO2 trial PFS robust mean 95  robust confidence interval was 4473 weeks 4103 4843 for Everolimus + Exemestane and 2298 weeks 1988 2608 for Placebo + Exemestane The QAPFS robust mean 95  robust confidence interval for the treatment arms of the trial was 3009 2760 3258 for Everolimus + Exemestane and 1627 1407 1846 for Placebo + Exemestane respectively Using QAPFS as an outcome measure provides a complete picture of the benefit induced by the treatment arms of the BOLERO2 trial The benefit of Everolimus + Exemestane over Placebo + Exemestane observed in the trial is maintained in this analysis The approach and estimates obtained as part of our analysis can serve as a basis for cost effectiveness analyses of the treatment arms of the BOLERO2 trialThe authors would like to thank Dr Janet Barber and Dr Ellen Campbell from the Division of Economic Social and Administrative Pharmacy College of Pharmacy and Pharmaceutical Sciences Florida AM University for their insightful comments on earlier versions of the paper

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