Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Breast Cancer Res Treat

Search In Journal Title:

Abbravation: Breast Cancer Research and Treatment

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

ISSN

1573-7217

Search In ISSN:
Search In Title Of Papers:

Small inhibitor of Bcl2 HA141 selectively enha

Authors: Elif Damla Arisan Ozgur Kutuk Tugsan Tezil Cagri Bodur Dilek Telci Huveyda Basaga
Publish Date: 2009/02/24
Volume: 119, Issue: 2, Pages: 271-
PDF Link

Abstract

Inhibition or downregulation of Bcl2 represents a new therapeutic approach to bypass chemoresistance in cancer cells Therefore we explored the potential of this approach in breast cancer cells Cisplatin and paclitaxel induced apoptosis in a dosedependent manner in MCF7 drugsensitive and MDAMB231 druginsensitive cells Furthermore when we transiently silenced Bcl2 both cisplatin and paclitaxel induced apoptosis more than parental cells Dose dependent induction of apoptosis by drugs was enhanced by the pretreatment of these cells with HA141 a Bcl2 inhibitor Although the effect of cisplatin was significant on both cell lines the effect of paclitaxel was much less potent only in MDAMB231 cells To further understand the distinct role of drugs in MDAMB231 cells pretreated with HA141 caspases and Bcl2 family proteins were studied The apoptotic effect of cisplatin with or without HA141 pretreatment is shown to be caspasedependent Among proapoptotic Bcl2 proteins Bax and Puma were found to be upregulated whereas Bcl2 and BclxL were downregulated when cells were pretreated with HA141 followed by paclitaxel or cisplatin Enforced Bcl2 expression in MDAMB231 cells abrogated the sensitizing effect of HA141 in cisplatin induced apoptosis These results suggest that the potentiating effect of HA141 is drug and cell type specific and may not only depend on the inhibition of Bcl2 Importantly alteration of other proapoptotic or antiapoptotic Bcl2 family members may dictate the apoptotic response when HA141 is combined with chemotherapeutic drugs

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Variability in hormone and growth factor receptor expression in primary versus recurrent, metastatic, and post-neoadjuvant breast carcinoma
  2. Trends in 5-year survival rates among breast cancer patients by hormone receptor status and stage
  3. Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohort
  4. Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast
  5. Feature extraction via composite scoring and voting in breast cancer
  6. Biopsy sampling of breast lesions: comparison of core needle- and vacuum-assisted breast biopsies
  7. Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha
  8. A study of the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal women with estrogen receptor-positive breast cancer
  9. Bcl-2 expression correlates with lymphovascular invasion and long-term prognosis in breast cancer
  10. Diagnosis and management of primary breast sarcoma
  11. Recurrent read-through fusion transcripts in breast cancer
  12. Anastrozole versus tamoxifen as adjuvant therapy for Japanese postmenopausal patients with hormone-responsive breast cancer: efficacy results of long-term follow-up data from the N-SAS BC 03 trial
  13. Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
  14. Accuracy of magnetic resonance in suspicious breast lesions: a systematic quantitative review and meta-analysis
  15. The impact of oophorectomy on survival after breast cancer in BRCA1 -positive breast cancer patients
  16. Impact of carpal tunnel syndrome surgery on women with breast cancer-related lymphedema
  17. A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer
  18. Effect of adding gefitinib to neoadjuvant chemotherapy in estrogen receptor negative early breast cancer in a randomized phase II trial
  19. Body weight and risk of breast cancer in BRCA1/2 mutation carriers
  20. Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients
  21. Patterns of nodal staging during breast conservation surgery in the medicare patient: will the ACOSOG Z0011 trial change the pattern of care?
  22. Tumor angiogenesis as prognostic and predictive marker for chemotherapy dose-intensification efficacy in high-risk breast cancer patients within the WSG AM-01 trial
  23. CYP1B1 and predisposition to breast cancer in Poland
  24. Capecitabine plus paclitaxel versus epirubicin plus paclitaxel as first-line treatment for metastatic breast cancer: efficacy and safety results of a randomized, phase III trial by the AGO Breast Cancer Study Group
  25. Focused antibody response in plasma cell-infiltrated non-medullary (NOS) breast cancers
  26. The effect of delays in treatment for breast cancer metastasis on survival
  27. Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS04 trial
  28. Transactivation of ERα by Rosiglitazone induces proliferation in breast cancer cells
  29. Family history of breast cancer in first-degree relatives and triple-negative breast cancer risk
  30. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling
  31. MRI screening of women with hereditary predisposition to breast cancer: diagnostic performance and survival analysis
  32. HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
  33. Metformin and breast cancer risk: a meta-analysis and critical literature review
  34. XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects
  35. Mechanisms of estrogen-independent breast cancer growth driven by low estrogen concentrations are unique versus complete estrogen deprivation
  36. Association of progesterone receptor gene ( PGR ) variants and breast cancer risk in African American women
  37. Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12–93
  38. RC0639: phase II study of paclitaxel, trastuzumab, and lapatinib as adjuvant therapy for early stage HER2-positive breast cancer
  39. Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature
  40. Postmenopausal estrogen monotherapy–associated breast cancer risk is modified by CYP17A1 _-34_T>C polymorphism
  41. Women’s features and inter-/intra-rater agreement on mammographic density assessment in full-field digital mammograms (DDM-SPAIN)
  42. Promoter methylation reduces C/EBP δ (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors
  43. A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland
  44. Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73
  45. Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer
  46. Increased racial differences on breast cancer care and survival in America: historical evidence consistent with a health insurance hypothesis, 1975–2001
  47. Cytosolic levels of TFF1/pS2 in breast cancer: their relationship with clinical–pathological parameters and their prognostic significance
  48. A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences
  49. Trends in the use of mastectomy in women with small node-negative breast cancer treated at US academic centers
  50. Can additional immunohistochemistry staining replace the surgical excision for the diagnosis of papillary breast lesions classified as benign on 14-gage core needle biopsy?
  51. Long-term quality of life after breast cancer: a French registry-based controlled study
  52. Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis
  53. Using quality-adjusted progression-free survival as an outcome measure to assess the benefits of cancer drugs in randomized-controlled trials: case of the BOLERO-2 trial
  54. Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients
  55. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells
  56. MR imaging features associated with distant metastasis-free survival of patients with invasive breast cancer: a case–control study
  57. Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer
  58. Simplifying clinical use of the genetic risk prediction model BRCAPRO
  59. The association between ERCC2 Asp312Asn polymorphism and breast cancer risk: a meta-analysis involving 22,766 subjects
  60. Double heterozygotes among breast cancer patients analyzed for BRCA1, CHEK2, ATM, NBN/NBS1 , and BLM germ-line mutations
  61. Down-regulation of PHLDA1 gene expression is associated with breast cancer progression
  62. One-day core needle biopsy in a breast clinic: 4 years experience
  63. Preoperative breast MRI in early-stage breast cancer
  64. Population-based survival-cure analysis of ER-negative breast cancer
  65. Characterisation of tumour-infiltrating macrophages: impact on response and survival in patients receiving primary chemotherapy for breast cancer
  66. PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer
  67. Effects of music therapy on pain among female breast cancer patients after radical mastectomy: results from a randomized controlled trial
  68. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
  69. The association of reproductive factors and breastfeeding with long term survival from breast cancer
  70. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer
  71. Non-invasive quantification of tumor vascular architecture during docetaxel-chemotherapy
  72. Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer
  73. Genetic variants in trinucleotide repeat-containing 9 ( TNRC9 ) are associated with risk of estrogen receptor positive breast cancer in a Chinese population
  74. Breast cancer in young women
  75. Phase II trial of a novel capecitabine dosing schedule in combination with lapatinib for the treatment of patients with HER2-positive metastatic breast cancer
  76. Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties
  77. Evolution of sites of recurrence after early breast cancer over the last 20 years: implications for patient care and future research
  78. Plasma S100P level as a novel prognostic marker of metastatic breast cancer
  79. A Study on the Association of Cytochrome-P450 1A1 Polymorphism and Breast Cancer Risk in North Indian Women
  80. Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer
  81. Evaluating the organization and delivery of breast cancer services: use of performance measures to identify knowledge gaps
  82. Locoregional lymph node involvement on 18F-FDG PET/CT in breast cancer patients scheduled for neoadjuvant chemotherapy
  83. Acknowledgement of reviewers 2015
  84. A 38-gene expression signature to predict metastasis risk in node-positive breast cancer after systemic adjuvant chemotherapy: a genomic substudy of PACS01 clinical trial
  85. Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan
  86. Toxicity of (neo)adjuvant chemotherapy for BRCA1 - and BRCA2 -associated breast cancer
  87. Detection and prevalence of disseminated tumor cells from the bone marrow of early stage male breast cancer patients
  88. Social networks, social support and burden in relationships, and mortality after breast cancer diagnosis
  89. Mechanistic analysis of the antitumor efficacy of human natural killer cells against breast cancer cells
  90. Interaction between smoking history and gene expression levels impacts survival of breast cancer patients
  91. Mammary field cancerization: molecular evidence and clinical importance
  92. Personal breast: customizing agents and biomarkers for optimal adjuvant endocrine therapy
  93. The impact of diabetes on survival following breast cancer
Search Result: