Authors: Maribel D Lacambra Christopher C Lam Paulo Mendoza Siu Ki Chan Alex M Yu Julia Y S Tsang Puay Hoon Tan Gary M Tse
Publish Date: 2011/06/23
Volume: 132, Issue: 3, Pages: 917-923
Abstract
Needle biopsy is now the initial investigation of choice for the preoperative diagnosis of breast lesions This includes core needle biopsy CNB and vacuumassisted biopsy VAB with or without radiologic assistance The performance indices of both of these biopsy techniques were evaluated In a large cohort of patients with breast lesions including 464 cases 285 CNB and 179 VAB with confirmed outcomes the diagnostic accuracy was compared using parameters including quantitation of the sampling based on the total number of cores taken cores containing breast parenchyma and cores with lesion and nonepithelial changes including necrosis and calcification CNB showed a 99 PPV 94 NPV 96 sensitivity and 99 specificity whereas VAB demonstrated a 100 PPV 100 NPV 100 sensitivity and 100 specificity The correct diagnosis in CNB was proportional to the number of cores extracted whereas accuracy of VAB was independent of the total number of cores taken There was a positive correlation between the presence of calcification and malignancy in CNB but not detected under VAB CNB and VAB were equally efficient in palpable lesions in detecting necrosis and calcification Large calcification was found to be associated with malignancy in both CNB and VAB In nonpalpable lesions VAB was more effective in the detection of calcification The diagnostic accuracy of VAB appeared to be independent of number of cores sampled whereas CNB required a minimum of 3–4 cores to achieve high diagnostic accuracy
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