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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1007/s11192-011-0501-z

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ISSN

1573-7217

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Loss of expression of chromosome 16q genes DPEP1 a

Authors: Andrew R Green Sophie Krivinskas Peter Young Emad A Rakha E Claire Paish Desmond G Powe Ian O Ellis
Publish Date: 2008/01/23
Volume: 113, Issue: 1, Pages: 59-66
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Abstract

Background Loss of the chromosomal material at 16q is the most frequent genetic event in invasive and in situ LCIS lobular carcinoma of the breast However the smallest region of overlap at 16q is not restricted to just the CDH1 locus harbouring Ecadherin suggesting that neighbouring genes might be involved in the development and progression of these tumours Potential novel tumour suppressor genes TSG at 16q include CCCTCbinding factor CTCF Decreased Expression in Renal and Prostate Cancer DERPC and Dipeptidase 1 DPEP1 The aim of this study is to assess the expression of these genes in LCIS and compare them with normal breast using CDH1 as a control in order to evaluate their role as TSGs Methods Cells from LCIS cases and normal breast lobules were microdissected and expression of target genes were quantified using realtime PCR In addition immunohistochemistry IHC for Ecadherin and CTCF was performed on paraffin processed LCIS n = 49 and normal breast cases Results All LCIS showed negative expression of Ecadherin Similar to CDH1 CTCF and DPEP1 gene expression was significantly lower in LCIS cases compared with normal cases P  005 CTCF IHC expression showed significant reduction in LCIS compared to normal parenchymal cells However there was no difference in expression of DERPC between LCIS and normal breast tissue Conclusions In addition to CDH1 loss of CTCF and DPEP1 gene expression suggest they are possible TSG in breast cancer and may similar to CDH1 be potentially utilised as markers of predisposition of women diagnosed with LCIS

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