Authors: Patricia A Ganz Laurel A Habel Erin K Weltzien Bette J Caan Steven W Cole
Publish Date: 2011/04/11
Volume: 129, Issue: 2, Pages: 549-
Abstract
There is increasing interest in the relationship between host lifestyle factors and the outcomes of cancer treatment Behavioral factors comorbid conditions and noncancerrelated pharmaceutical exposures may affect breast cancer BC outcomes We used observational data from the LACE Study cohort women with early stage BC from the Kaiser Permanente Northern California Cancer Registry to examine the association between beta blockers BBs and/or angiotensinconverting enzyme inhibitors ACEi and BC recurrence BCspecific mortality and overall mortality Among 1779 women there were 292 BC recurrences 174 BC deaths and 323 total deaths 23 were exposed to either a BB and/or an ACEi These drugs were associated with older age postmenopausal status tamoxifen therapy greater prediagnosis BMI hypertension and diabetes In Cox proportional hazards models ACEi exposure was associated with BC recurrence HR 156 95 CI 102 239 P = 004 but not causespecific or overall mortality Combined ACEi and BB were associated with overall mortality HR 194 95 CI 122 310 P = 001 BB exposure was associated with lower hazard of recurrence and causespecific mortality However there was no evidence of a dose response with either medication For recurrence and causespecific mortality BB combined with ACEi was associated with a lower HR for the outcome than when ACEi alone was used These hypothesis generating findings suggest that BC recurrence and survival were associated with exposure to two commonly used classes of antihypertensive medications These observations need to be confirmed and suggest that greater attention should focus on the potential role of these commonly used medications in BC outcomesFunding source for the conduct of this research was provided to the following authors Ganz the Breast Cancer Research Foundation the Jonsson Comprehensive Cancer Center Foundation R01 CA109650 Habel R01 CA98838 and R01 CA129059 Weltzien R01 CA129059 Caan R01 CA129059 and Cole R01 CA116778
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