Family history of breast cancer in firstdegree re

Authors: Amanda I Phipps Diana S M Buist Kathleen E Malone William E Barlow Peggy L Porter Karla Kerlikowske Christopher I Li

Publish Date: 2010/09/03

Volume: 126, Issue: 3, Pages: 671-678

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Abstract

Triplenegative breast cancer accounts for less than 20 of breast cancers overall but is the predominant subtype among carriers of mutations in BRCA1 However few studies have assessed the association between breast cancer family history and risk of triplenegative breast cancer We examined the relationship between having a family history of breast cancer in firstdegree relatives and risk of triplenegative breast cancer and risk of two other breast cancer subtypes defined by tumor marker expression We evaluated data collected by the Breast Cancer Surveillance Consortium from 2599946 mammograms on 1054466 women among whom 15 reported a firstdegree family history of breast cancer Using Cox regression in this cohort we evaluated subtypespecific associations between family history and risk of triplenegative N = 705 estrogen receptorpositive ER+ N = 10026 and hormone receptornegative/HER2expressing ER−/PR−/HER2+ N = 308 breast cancer among women aged 40–84 years Firstdegree family history was similarly and significantly associated with an increased risk of all the subtypes hazard ratio HR = 173 95 confidence interval CI 143–209 HR = 162 95 CI 154–170 and HR = 156 95 CI 115–213 for triplenegative ER+ and ER−/PR−/HER2+ respectively Risk of all the subtypes was most pronounced among women with at least two affected firstdegree relatives versus women with no affected firstdegree relatives HRtriplenegative = 266 95 CI 166–427 HRER+ = 205 95 CI 179–236 HRER−/PR−/HER2+ = 225 95 CI 099–508 Having a firstdegree family history of breast cancer was associated with an increased risk of triplenegative breast cancer with a magnitude of association similar to that for the predominant ER+ subtype and ER−/PR−/HER2+ breast cancerWe thank the participating women mammography facilities and radiologists for the data they have provided for this study A list of the BCSC investigators and procedures for requesting BCSC data for research purposes are provided at http//breastscreeningcancergov/This study was supported by a National Cancer Institutefunded Breast Cancer Surveillance Consortium cooperative agreement U01CA63740 U01CA86076 U01CA86082 U01CA63736 U01CA70013 U01CA69976 U01CA63731 and U01CA70040 The collection of cancer data used in this study was supported in part by several state public health departments and cancer registries throughout the US For a full description of these sources please see http//breastscreeningcancergov/work/acknowledgementhtml This publication was supported by grant number T32 CA09168 and R25CA94880 from the National Cancer Institute National Institutes of Health The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health

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