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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1002/app.33211

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ISSN

1573-7217

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Is adjuvant chemotherapy of benefit for postmenopa

Authors: Olivia Pagani Shari Gelber Edda Simoncini Monica CastiglioneGertsch Karen N Price Richard D Gelber Stig B Holmberg Diana Crivellari John Collins Jurij Lindtner Beat Thürlimann Martin F Fey Elizabeth Murray John F Forbes Alan S Coates Aron Goldhirsch for the International Breast Cancer Study Group
Publish Date: 2008/10/25
Volume: 116, Issue: 3, Pages: 491-500
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Abstract

To compare the efficacy of chemoendocrine treatment with that of endocrine treatment ET alone for postmenopausal women with highly endocrine responsive breast cancer In the International Breast Cancer Study Group IBCSG Trials VII and 12–93 postmenopausal women with nodepositive estrogen receptor ERpositive or ERnegative operable breast cancer were randomized to receive either chemotherapy or endocrine therapy or combined chemoendocrine treatment Results were analyzed overall in the cohort of 893 patients with endocrineresponsive disease and according to prospectively defined categories of ER age and nodal status STEPP analyses assessed chemotherapy effect The median followup was 13 years Adding chemotherapy reduced the relative risk of a diseasefree survival event by 19 P = 002 compared with ET alone STEPP analyses showed little effect of chemotherapy for tumors with high levels of ER expression P = 007 or for the cohort with one positive node P = 003 Chemotherapy significantly improves diseasefree survival for postmenopausal women with endocrineresponsive breast cancer but the magnitude of the effect is substantially attenuated if ER levels are highWe thank the patients physicians nurses and data managers who have participated in the International Breast Cancer Study Group see Appendix trials now and for the past 30 years The IBCSG is funded in part by Swiss Group for Clinical Cancer Research SAKK Frontier Science and Technology Research Foundation FSTRF The Cancer Council Australia Australian New Zealand Breast Cancer Trials Group National Health Medical Research Council National Cancer Institute CA75362 Swedish Cancer Society Cancer Research Switzerland/Oncosuisse Cancer Association of South Africa Foundation for Clinical Cancer Research of Eastern Switzerland OSKKMembers from 1998 to 2008 S Aebi A S Coates M Colleoni J P Collins H Cortés Funes R D Gelber A Goldhirsch M Green A Hiltbrunner S B Holmberg P Karlsson I Kössler I Láng J Lindtner F Paganetti M de Stoppani CM Rudenstam HJ Senn R Stahel B Thürlimann A Veronesi

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  4. Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast
  5. Feature extraction via composite scoring and voting in breast cancer
  6. Biopsy sampling of breast lesions: comparison of core needle- and vacuum-assisted breast biopsies
  7. Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha
  8. A study of the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal women with estrogen receptor-positive breast cancer
  9. Bcl-2 expression correlates with lymphovascular invasion and long-term prognosis in breast cancer
  10. Diagnosis and management of primary breast sarcoma
  11. Recurrent read-through fusion transcripts in breast cancer
  12. Anastrozole versus tamoxifen as adjuvant therapy for Japanese postmenopausal patients with hormone-responsive breast cancer: efficacy results of long-term follow-up data from the N-SAS BC 03 trial
  13. Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
  14. Accuracy of magnetic resonance in suspicious breast lesions: a systematic quantitative review and meta-analysis
  15. The impact of oophorectomy on survival after breast cancer in BRCA1 -positive breast cancer patients
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  19. Body weight and risk of breast cancer in BRCA1/2 mutation carriers
  20. Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients
  21. Patterns of nodal staging during breast conservation surgery in the medicare patient: will the ACOSOG Z0011 trial change the pattern of care?
  22. Tumor angiogenesis as prognostic and predictive marker for chemotherapy dose-intensification efficacy in high-risk breast cancer patients within the WSG AM-01 trial
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  36. Association of progesterone receptor gene ( PGR ) variants and breast cancer risk in African American women
  37. RC0639: phase II study of paclitaxel, trastuzumab, and lapatinib as adjuvant therapy for early stage HER2-positive breast cancer
  38. Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature
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  42. A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland
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  44. Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer
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  47. A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences
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  57. Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer
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  76. Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties
  77. Evolution of sites of recurrence after early breast cancer over the last 20 years: implications for patient care and future research
  78. Plasma S100P level as a novel prognostic marker of metastatic breast cancer
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