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Title of Journal: Breast Cancer Res Treat

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Abbravation: Breast Cancer Research and Treatment

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Springer US

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DOI

10.1007/s11276-016-1243-x

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ISSN

1573-7217

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The effect of delays in treatment for breast cance

Authors: Su Yon Jung Susan M Sereika Faina Linkov Adam Brufsky Joel L Weissfeld Margaret Rosenzweig
Publish Date: 2011/07/08
Volume: 130, Issue: 3, Pages: 953-964
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Abstract

It is generally accepted that delay in receiving treatment for breast cancer results in adverse outcomes The purpose of this study was to evaluate the impact of delay in treatment after the diagnosis of metastatic disease on survival measured from metastatic breast cancer diagnosis and from first treatment while controlling for immortal time effect among patients with metastatic breast cancer A total of 553 patients with breast cancer metastasis diagnosis from one large urban practice have been followed between January 1 1999 and June 30 2008 Prognostic factors and outcomes of these patients were analyzed using logrank test and Cox regression model Backward stepwise selection of covariates was conducted to assess the association of treatment delay with survival The median survival was 40 months range 1–114 months with 265 479 women alive and 288 521 having died at the end of the followup period Treatment delays of more than 12 weeks had impact on poor survival from first treatment than the delays of 4–12 weeks with borderline significance level HR 176 95 CI 099–313 P = 0056 in multivariate analysis adjusted by BMI history of hypertension ER/PR status HER2 status number of metastatic sites and liver metastasis Moreover the interval of 12–24 weeks compared to the interval of 4–12 weeks was associated with greater risk of death from first treatment HR 239 95 CI 119–477 P = 0014 The treatment delay interval of 12 weeks was not related with survival since metastatic breast cancer diagnosis compared to the 4–12 weeks of treatment delays This study demonstrated that delays of over 12 weeks in receiving treatment for metastatic breast cancer were related to adverse survival outcomes measured from initiation of first treatment The findings of this study support targeted efforts to ensure prompt treatment initiation in patients diagnosed with metastatic breast cancer

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