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Title of Journal: J Nanopart Res

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Abbravation: Journal of Nanoparticle Research

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Springer Netherlands

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DOI

10.1006/spmi.1995.1079

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ISSN

1572-896X

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Folic acidconjugated graphene oxide as a transpor

Authors: Xiufen Cao Fuli Feng Yinsong Wang Xiaoying Yang Hongquan Duan Yongshen Chen
Publish Date: 2013/09/03
Volume: 15, Issue: 10, Pages: 1965-
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Abstract

Functionalized graphene oxide GO with folic acidconjugated chitosan oligosaccharide FACO containing quaternary ammonium groups GOFACO+ was successfully prepared The formation and composition of GOFACO+ were confirmed by FTIR UV–Vis AFM TGA and zetapotential Cell experiments show that cellular uptake of fluorescein FAMlabeled DNA sequence FAMDNA delivered by GOFACO+ exhibits higher efficiency in doxorubicin chloride Doxresistant MCF7 human breast cancer cells MCF7/Dox with folate receptor overexpressed than that delivered by chitosan oligosaccharide COfunctionalized graphene oxides GOCO+ without folic acid modification and in human lung cancer A549 cells with folate receptor negatively expressed The loading efficiency of Dox on GOFACO+ was 5684 μg mg−1 at the initial Dox concentration of 05 mg mL−1 and in vitro release of Dox showed strong pH dependence MDR1 siRNA transfected by GOFACO+ could efficiently knockdown the MDR1 mRNA and Pgp expression levels in MCF7/Dox cells GOFACO+ shows no obvious toxicity even at 500 μg mL−1 The sequential deliveries of MDR1 siRNA and Dox by GOFACO+ exhibited much higher cytotoxicity against MCF7/Dox cells than only delivery of Dox by GOFACO+ when Dox concentration is lower than 25 μg mL−1 while excess 80  cells were killed in the two cases when Dox concentration is higher than 30 μg mL−1 Taken together this functionalized GO has potential applications for targeted intracellular delivery of antitumor drugs and genes

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