Authors: HuiJun Li AnQi Zhang Li Sui DongJin Qian Meng Chen
Publish Date: 2015/02/28
Volume: 17, Issue: 2, Pages: 111-
Abstract
Watersoluble and wellstabilized silver nanoparticles NPs of small size have been synthesized using hyaluronan HA and Tween 80 as reducing and stabilizing agents The effect of reaction conditions on the formation process of silver NPs was studied and an aggregative growth mechanism of the silver NPs dominated in HA/Tween 80 system at pH 12 has been proposed The obtained Ag NPs were characterized by UV–Vis spectroscopy transmission electron microscopy Xray powder diffraction and Xray photoelectron spectroscopy Moreover the stability of the HA–Tween 80silver NPs in normal saline was also studied and a flexible blend membrane containing chitosan gelatin and the HA–Tween 80silver NPs was prepared for further biological applications Due to the high specific surface area and improved stability of silver NPs the chitosan–gelatinsilver membrane has shown high antibacterial activity for strains of Escherichia coli The cell viability tests indicate that the polymer membrane is noncytotoxic to HepG2 cells which might be attributed to its good biocompatibility
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