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Title of Journal: J Nanopart Res

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Abbravation: Journal of Nanoparticle Research

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Springer Netherlands

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DOI

10.1016/0090-3019(95)00065-8

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ISSN

1572-896X

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Ciprofloxacin nanoniosomes for targeting intracel

Authors: Vajihe Akbari Daryoush Abedi Abbas Pardakhty Hojjat SadeghiAliabadi
Publish Date: 2013/03/12
Volume: 15, Issue: 4, Pages: 1556-
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Abstract

In order to propose nonionic surfactant vesicles niosomes for the treatment of intracellular infections a remote loading method active drug encapsulation followed by sonication was used to prepare nanoniosome formulations containing ciprofloxacin CPFX Size analysis size distribution and zeta potentials of niosomes were evaluated and then their antimicrobial activity cellular uptake cytotoxicity intracellular distribution and antibacterial activity against intracellular Staphylococcus aureus infection of murine macrophagelike J774 cells were investigated in comparison to free drug Our findings reveal that size and composition of the niosome formula can influence their in vitro biological properties Vesicles in the 300–600 nm size range were phagocytosed to a greater degree by macrophages in comparison to other size vesicles The minimum inhibitory concentrations MICs of CPFXloaded niosomes were two to eightfold lower than MICs of free CPFX In addition niosome encapsulation of CPFX provided high intracellular antimicrobial activities while free CPFX is ineffective for eradicating intracellular forms of S aureus Encapsulation of CPFX in niosomes generally decreased its in vitro cytotoxicity Our results show that niosomes are suitable drug delivery systems with good efficacy and safety properties to be proposed for drug targeting against intracellular infections

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