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Title of Journal: J Nanopart Res

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Abbravation: Journal of Nanoparticle Research

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Springer Netherlands

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DOI

10.1007/978-1-4899-7531-7_17

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1572-896X

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The inclusion into PLGA nanoparticles enables αbi

Authors: Laura Marongiu Marta Donini Michele Bovi Massimiliano Perduca Federico Vivian Alessandro Romeo Sofia Mariotto Hugo L Monaco Stefano Dusi
Publish Date: 2014/07/18
Volume: 16, Issue: 8, Pages: 2554-
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Abstract

αbisabolol a natural sesquiterpene alcohol has generated considerable interest for its antiinflammatory activity Since the mechanisms of this antiinflammatory action remain poorly understood we investigated whether αbisabolol affects the release of proinflammatory cytokines IL12 IL23 IL6 and TNFα by human dendritic cells DCs We found that αbisabolol did not induce the secretion of these cytokines and did not affect their release induced upon DC challenge with lipopolysaccharide LPS a wellknown immune cell stimulator As αbisabolol is scarcely ingested by the cells we wondered whether the inclusion of αbisabolol into nanoparticles could favor its internalization by DCs and consequently its effects on cytokine secretion We then prepared and characterized polylacticcoglycolic acid PLGA nanoparticles with a dynamic light scattering peak centered at 154 nm and a half width at half maximum of about 48 nm These particles were unable to affect per se cytokine secretion by both resting and LPSstimulated DCs and were internalized by human DCs as demonstrated by confocal microscopy analysis We then loaded PLGA nanoparticles with αbisabolol and we observed that PLGAassociated αbisabolol did not stimulate the cytokine release by resting DCs but decreased IL12 IL23 IL6 and TNFα secretion by LPSstimulated DCs Our results indicate that αbisabolol inclusion into PLGA nanoparticles represents a very promising tool for designing new antiinflammatory antipyretic and possibly immunosuppressive therapeutic strategies

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