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Title of Journal: J Nanopart Res

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Abbravation: Journal of Nanoparticle Research

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Springer Netherlands

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DOI

10.1007/bf02632512

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1572-896X

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Radiolabeled cyclic arginineglycineaspartic RGD

Authors: Shengming Deng Wei Zhang Bin Zhang Ruoyu Hong Qing Chen Jiajia Dong Yinyiin Chen Zhiqiang Chen Yiwei Wu
Publish Date: 2015/01/13
Volume: 17, Issue: 1, Pages: 19-
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Abstract

Ultrasmall superparamagnetic iron oxide nanoparticles USPIOs modified with a novel cyclic arginineglycineaspartate RGD peptide were made and radiolabeled as singlephoton emission computed tomography SPECT and magnetic resonance imaging MRI dualmodality agents for imaging of breast cancer The probe was tested both in vitro and in vivo to determine its receptor targeting efficacy and feasibility for SPECT and MRI The radiochemical syntheses of 125IcRGDUSPIO were accomplished with a radiochemical purity of 9605 ± 033  High radiochemical stability was found in fresh human serum and in phosphatebuffered saline The average hydrodynamic size of 125IcRGDUSPIO determined by dynamic light scattering was 513 nm Results of in vitro experiments verified the specificity of the radiolabeled nanoparticles to tumor cells Preliminary biodistribution studies of 125Iradiolabeled cRGDUSPIO in Bcap37bearing nude mice showed that it had long circulation halflife high tumor uptake and high initial blood retention with moderate liver uptake In vivo tumor targeting and uptake of the radiolabeled nanoparticles in mice model were visualized by SPECT and MRI collected at different time points Our results strongly indicated that the 125IcRGDUSPIO could be used as a promising bifunctional radiotracer for early clinical tumor detection with high sensitivity and high spatial resolution by SPECT and MRI

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