Authors: P Dziurdzik L Krawczyk P Jalowiecki Z KonderaAnasz L Menon
Publish Date: 2004/08/10
Volume: 53, Issue: 8, Pages: 338-343
Abstract
Materials and methodsSerum IL10 levels in 46 adults multiprofile ICU teaching hospital with traumatic brain injury TBI N = 18 nontraumatic intracranial hemorrhage SAH N = 11 and polytrauma with concomitant brain injury POL N = 17 were measured using ELISA Relationship of IL10 and initial diagnosis clinical state outcome and risk of infection development was evaluatedResultsIL10 was detectable in the serum of all but one patient on ICU admission 566 ± 919 pg/ml mean ± SD No statistically significant differences in IL10 between TBI SAH and POL groups as well as between survivors and nonsurvivors on any day were found No correlation between IL10 and GCS or SAPS II was seen Significant fall in serum IL10 during the first 4 days of injury in patients of all subgroups was observed Patients with initial serum IL10 below 77pg/ml were at significantly higher risk of development of any infection within the first week of injuryConclusionsAfter acute brain injury serum IL10 in adults is detectable independent of CNS lesion type Its systemic release is strongly individualized Serum IL10 on ICU admission may have some prognostic value to predict development of infection in patients with CNS lesions
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