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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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1420-908X

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Modelling experimental uveitis barrier effects in

Authors: David Nicholson Emma C Kerr Owen G Jepps Lindsay B Nicholson
Publish Date: 2012/04/10
Volume: 61, Issue: 7, Pages: 759-773
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Abstract

The presence of the barrier is critical to the ability of the model to qualitatively reproduce the experimental data However barrier breakdown is not sufficient to produce a surge of cells into the eye which depends also on asymmetry in the rates at which cells can penetrate the barrier Antigenpresenting cell APC generation also plays a critical role and we can derive from the model the ratio for APC production under inflammatory conditions relative to production in the resting state which has a value that agrees closely with that found by experimentOur modelling approach is based on the principles of immuneresponse models that have been proposed and analysed in earlier literature The model is expressed in terms of the customary mass action equations where it is assumed that concentration heterogeneities are unimportant a significant distinction from earlier models is that different concentrations can exist on opposite sides of the barrier The possible dynamic processes are characterised by rate constants controlling production proliferation death apoptosis for cells activation or transformation differentiation of one species to another produced by contact with another species in the system and permeation through the barrier


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