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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1002/9781118648766.app1

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1420-908X

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The investigation of synovial genomic targets of b

Authors: Kenji Oki Fumio Tsuji Koji Ohashi Masaaki Kageyama Hiroyuki Aono Minoru Sasano
Publish Date: 2009/03/17
Volume: 58, Issue: 9, Pages: 571-584
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Abstract

Normal human FLS were treated with IL1β in the presence or absence of 10 and 100 μM bucillamine for 6 h Total RNA was extracted and global gene expression levels were detected using a 44 k human whole genome array Data were analyzed using Ingenuity pathway analysisBucillamine effectively inhibited fibroblast growth factor FGF signaling and tight junction signaling activated by IL1β in FLS Suppression of these signal pathways may correlate with the pharmacologic mechanisms of bucillamine In particular the suppression of FGF signaling by bucillamine is remarkable because the activation of FGF signaling may be involved in rheumatoid arthritis pathology

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