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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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Springer Basel

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DOI

10.1016/0039-6028(93)91127-b

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1420-908X

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Chemerin/chemR23 axis in inflammation onset and re

Authors: Francesco Mariani Luca Roncucci
Publish Date: 2014/12/30
Volume: 64, Issue: 2, Pages: 85-95
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Abstract

Chemerin is an adipokine secreted by adipocytes and associated with obesity insulin resistance and metabolic syndrome Different chemerin fragments with pro or antiinflammatory action can be produced depending on the class of proteases predominating in the microenvironment Chemerin binds to three receptors especially to chemR23 expressed on various cells as dendritic cells macrophages and natural killer cells regulating chemotaxis towards the site of inflammation and activation status Recently the chemerin/chemR23 axis has attracted particular attention for the multiple roles related to the control of inflammation metabolism and cancerogenesis in different organs and systems as lung allergy and cancer skin psoriasis lupus cancer wound repair cardiovascular system lipid profile and atherosclerosis reproductive apparatus polycystic ovary syndrome follicular homoeostasis and digestive tract inflammatory bowel diseases and cancer This pathway may regulate immune responses by contributing both to the pathogenesis of inflammatory diseases and to the resolution of acute inflammation Thus chemerinderived peptides or other substances that may affect the chemerin/chemR23 axis could be used in the future for the treatment of many diseases including cancer at different sites

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