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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1007/bf01461162

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1420-908X

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Use of discriminant analysis in assessing pulmonar

Authors: Gregorino Paone Alvaro Leone Sandro Batzella Vittoria Conti Francesco Belli Laura De Marchis Alice Mannocci Giovanni Schmid Claudio Terzano
Publish Date: 2012/12/23
Volume: 62, Issue: 3, Pages: 325-332
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Abstract

To date no sufficiently sensitive and specific single marker has been found to predict the clinical course of sarcoidosis We designed a cohort study to investigate whether a panel of biomarkers measured in bronchoalveolar lavage BAL and peripheral blood could help predict pulmonary function worsening during the clinical course of sarcoidosisWe analyzed 30 individuals with histologically proven sarcoidosis At baseline participants underwent pulmonary function tests PFTs fiberoptic bronchoscopy and radiological investigations BAL and blood cellular profiles were obtained from all individuals and six proinflammatory molecules were quantified in BAL and serum PFTs were performed at followup visits over a 2year period Using discriminant function analysis a canonical variable was generated to optimize the accuracy of selected variables in predicting pulmonary function worsening and was validated on a subset of nine consecutive individuals with sarcoidosisA combination of 6 markers from BAL was able to predict pulmonary function worsening in 96  of patients 95  confidence interval CI 844–9981 We validated the generated formula on a group of nine patients with sarcoidosis obtaining 778  correct classification 95  CI 453–937

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