Authors: S E Andersson K Lexmüller K Alving G M Ekström
Publish Date: 2014/02/12
Volume: 48, Issue: 9, Pages: 491-496
Abstract
Objective and Design To correlate the changes in periarticular tissue levels of proinflammatory cytokines and endothelin1 ET1 to local pathophysiology in rats with antigeninduced arthritis AIA¶Materials The periarticular soft tissue was excised from sixtysix rats at different stages of AIA¶Methods The samples were homogenized and the levels of immune like LI reactivities were determined The levels in the arthritic joints were compared to those in nonarthritic tissue Statistical significance was determined by ANOVA followed by Fisher PLSD¶Results Compatible with a role in an early alarm reaction some mediators tumor necrosis factor αLI interleukin2LI and interferonγLI were elevated prior to the vascular inflammatory activity The curve for ET1LI closely followed the intensity of the inflammation whereas these parameters preceeded the elevation of interleukin1βLI¶Conclusions Transient waves of different mediators appear during the course of the arthritis This indicates the presence of active downregulatory mechanisms Here the model could differ from human rheumatoid arthritis
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