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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1016/j.apsusc.2009.12.109

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1420-908X

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Genomewide gene expression study indicates the an

Authors: A Falus M Fenyő K Éder A Madarasi
Publish Date: 2011/07/10
Volume: 60, Issue: 10, Pages: 965-
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Abstract

The incidence and duration of respiratory symptoms as well as the length of appropriate antibiotic therapy were measured Simultaneously the genomewide gene expression pattern was examined by whole genome cDNA microarray in peripheral lymphocytes of childrenTwenty of 25 children showed a marked clinical improvement while in five of 25 had poor response or no changes The gene expression pattern of the patients’ peripheral lymphocytes was compared in favorable and poor responders The lymphocytes of the children with a documented improved clinical response to polarized light therapy showed a decrease in the expression of chemokine genes such as CXCL1 CXCL2 CXCL3 and IL8 and in that of the TNFα gene On the contrary a rapid elevation was found in the expression of the gene encoding for CYP4F2 a leukotriene B4metabolizing enzyme In children with poor clinical response to polarized light therapy no similar changes were detected in the gene expression pattern of the lymphocytes

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