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Title of Journal: Inflamm res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1007/s10067-014-2530-5

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1420-908X

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Immunosuppressive properties of surfactant in alve

Authors: J Kerecman S B Mustafa M M Vasquez P S Dixon R Castro
Publish Date: 2008/03/28
Volume: 57, Issue: 3, Pages: 118-125
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Abstract

TNFα and IL1β secretion and nitric oxide NO formation following LPS stimulation were inhibited by treatment with surfactants or DPPC Furthermore LPSdependent NO production and iNOS protein levels were significantly suppressed in cells pretreated for one hour with beractant compared to beractant added simultaneously with or following LPS Additionally LPSstimulated oxidative burst measured by flow cytometry was significantly decreased by beractant Finally beractant inhibited the translocation of NFκB from cytoplasmic into nuclear extract in LPSstimulated NR8383 AMsExogenous surfactants and surfactant phospholipid inhibit secretion of proinflammatory cytokines and NO in NR8383 AMs The inhibitory effects of beractant on oxygen radical and LPSinduced NO formation may result from unique mechanisms of decreasing cell signaling The antiinflammatory activity of surfactant products used in the treatment of neonatal respiratory distress syndrome RDS may depend upon the specific preparation or dose used

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