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Title of Journal: Inflamm res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1007/s15013-013-0012-5

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1420-908X

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Fluctuation of annexinA1 positive mast cells in c

Authors: S M Oliani G A Panin Ciocca T A Pimentel A S Damazo L Gibbs M Perretti
Publish Date: 2008/10/02
Volume: 57, Issue: 10, Pages: 450-456
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Abstract

Granulomatous inflammation was induced by injection of croton oil and Freund’s complete adjuvant CO/FCA into the dorsal airpouches of mice Skin tissue samples were collected from control group 24 h timepoint i e before disease development and 7 14 21 28 and 42 days postCO/FCA treatmentHistopathological analyses revealed an ongoing inflammation characterized by an increased number of activated mast cells at sites of the chronic inflammatory reaction in all experimental groups Immunohistochemical analysis showed skin mast cells highly immunoreactive for annexinA1 both at an initial day 7 and a delayed day 28 phase of the inflammatory reactionThe observed timedependent modulation of mast cell activation during the granulomatous injury indicates that multiple pathways centred on annexinA1 might become activated at different stages of this chronic inflammatory response including the delayed and proresolving phase

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