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Title of Journal: Inflamm res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1007/s00468-008-0305-9

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1420-908X

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Emphasis Type="Italic"Oridonin/Emphasis promot

Authors: AP Hu JM Du JY Li JW Liu
Publish Date: 2008/03/20
Volume: 57, Issue: 4, Pages: 163-170
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Abstract

Oridonin is an entkaurene diterpenoid extracted from Isodon Serra and we have previously demonstrated its immunosuppressive effect Our goal was to study how Oridonin impacts CD4+/CD25+ regulatory T cells Tregs and Th1/Th2 balance as well as its effect on the antiinflammatory target HO1We set up a model of Th1 polarization in vitro using ConA stimulation ratios of CD4+/CD25+ Tregs confirmed by the expression of Foxp3 were measured by flow cytometry and levels of IL2 IFNγ TGFβ and IL10 were measured by ELISA In addition HO1 expression was measured without stimulation with ConA by RTPCR and Western blotting and HO1 level in vitro was then measured by enzyme activity assay p005 ttest was taken as the level of statistical significanceOridonin promoted differentiation towards CD4+/CD25+ Tregs inhibited IL2 and IFNγ but induced TGFβ and IL10 thus rectifed the Th1 polarization Moreover Oridonin induced the expression of HO1 mRNA and protein and HO1 activity in vitro was enhanced accordingly

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