Authors: Kristoffer M A Henningsen Morten S Olesen Maria Pedersen Lone Nielsen Stig Haunsø Helle Bruunsgaard Jesper Hastrup Svendsen
Publish Date: 2010/05/20
Volume: 59, Issue: 11, Pages: 965-969
Abstract
We included 192 patients with socalled lone AF and age 40 years or below and 188 healthy controls All patients were genotyped for single nucleotide polymorphisms SNPs in inflammatory genes using fluorescencebased realtime polymerase chain reaction PCR A casecontrol analysis of the C/C C/T and T/T genotypes on IL1A889 revealed a significant difference in both the frequency of genotypes p = 003 and in the allelic frequency p = 0015 These differences were not significant after Bonferroni corrections For IL1B511 IL10592 IL101082 IL18137 IL18607 and TNF308 there were no significant differences neither in genotype frequency nor in allelic frequency between the lone AF patients and the controlsThe study was supported by grants from “The Danish Heart Foundation 0810R68A2150B84122518” “The Research Foundation” at the Heart Centre at Rigshospitalet “Rigshospitalets forskningsudvalg” “Augustinus Fonden” “Direktør Ib Henriksens Fond” “Aase og Ejnar Danielsens Fond” “Arvid Nilssons Fond” “Lægernes Forskningsforening af 1891” “Tove and John Girotti’s Fond” “Direktør Kurt Bønnelycke og Hustru fru Grethe Bønnelyckes Fond” “The John and Birthe Meyer Foundation” and “The Danish Arrhythmia Research Centre DARC” The Centre of Inflammation and Metabolism is supported by a grant from the Danish National Research Foundation 0251255 The study was supported by unrestricted research grants from Biotronik Denmark St Jude Medical and Medtronic Denmark
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