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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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Springer Basel

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DOI

10.1002/pssb.2220610256

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ISSN

1420-908X

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Role of farnesoid X receptor in inflammation and r

Authors: Firdose Begum Shaik Durbaka V R Prasad Venkata Ramireddy Narala
Publish Date: 2014/11/07
Volume: 64, Issue: 1, Pages: 9-20
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Abstract

FXR is a liganddependent transcription factor belonging to the nuclear hormone receptor superfamily The accrued data have shown that the FXR plays important roles not only in bile acid lipid metabolism and carbohydrate homeostasis but also in inflammatory responses The antiinflammatory and antifibrotic effects of FXR on chronic inflammatory diseases are not well documentedFXR is highly expressed in liver intestine kidney and adrenals but with lower expression in fat tissue heart and recently it has been found to express in lungs too Primary bile acids cholic acid and chenodeoxycholic acid are the natural endogenous ligands for FXR GW4064 and 6αethylchenodeoxycholic acid are the synthetic highaffinity agonists An exhaustive literature survey revealed that FXR acts as a key metabolic regulator and potential drug target for many metabolic syndromes that include chronic inflammatory diseasesThis work was supported by the Department of Biotechnology BT/PR13396/BRB/10/756/2009 and the Science Engineering Research Board SR/FT/LS154/2009 Department of Science Technology Government of India New Delhi We thank Mr N Siva Sanker Department of Genetics for the art work

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