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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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SP Birkhäuser Verlag Basel

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DOI

10.1002/tie.5060060316

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1420-908X

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Lansiumamide B and SB204900 isolated from Emphas

Authors: Takuya Matsui Chihiro Ito Hiroshi Furukawa Tadashi Okada Masataka Itoigawa
Publish Date: 2013/01/17
Volume: 62, Issue: 3, Pages: 333-341
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Abstract

Mast cells play a central role in allergic and chronic inflammation Extracts from Clausena lansium Lour Skeels Rutaceae possess many pharmacological effects including antiinflammatory antioxidant anticancer and antitrichomonal activities In addition the leaves and fruit are used in Chinese folk medicine We have isolated and identified four known cinnamamides from this plant lansiumamide C lansamide I lansiumamide B and SB204900 However the biological activities of these compounds are not yet understood The purpose of this paper is to clarify the pharmacological effects of these compounds on mast cellsLansamide I lansiumamide B and SB204900 significantly decreased histamine release Furthermore lansiumamide B and SB204900treated cells also reduced the protein and/or mRNA levels of TNFα SB204900 markedly suppressed the phosphorylation of p38 MAPK

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