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Title of Journal: Inflamm Res

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Abbravation: Inflammation Research

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Springer Basel

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DOI

10.1007/bf02188925

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1420-908X

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Impact of melatonin receptor deletion on intracell

Authors: Astrid Kleber Sarah Altmeyer Beate Wolf Alexander Wolf Thomas Volk Tobias Fink Darius Kubulus
Publish Date: 2014/10/29
Volume: 63, Issue: 12, Pages: 1023-1033
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Abstract

Melatonin is known to influence immune functions and to ameliorate outcome after septic challenge but it is unknown whether this is mediated by melatonin receptor activation This study aimed to elucidate molecular differences in spleen and ex vivo splenocytes of wildtype WT and melatonin receptor double knockout mice KO after polymicrobial sepsisPlasma TNFα levels were consistently high after 1 h of CLI Basal circulating leukocyte numbers were slightly higher in KO animals We detected transcriptional differences in splenocytes of the knockout strain concerning proinflammatory mediators Expression levels of IL1β IL2 CXCR2 LSelectin TNFα CXCL2 and ICAM1 were strongly increased in splenocytes of KO mice Splenocytes of KO mice displayed reduced ERK and p38 as well as increased JNK phosphorylation None of the analyzed factors were influenced by melatonin in the culture medium

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