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Title of Journal: Arch Gynecol Obstet

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Abbravation: Archives of Gynecology and Obstetrics

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Springer-Verlag

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DOI

10.1007/s00404-005-0061-7

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ISSN

1432-0711

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Prothrombin G20210A mutation in cases with recurre

Authors: Salim Sehirali M Murat Inal Yusuf Yildirim Zuhal Balim Buket Kosova Tulin Karamizrak Muzaffer Sanci Nejat Topcuoglu Sivekar Tinar
Publish Date: 2005/09/28
Volume: 273, Issue: 3, Pages: 170-
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Abstract

Background Thrombophilic predisposition may be one of the underlying causes of recurrent miscariage RM The purpose of this study was to evaluate the Prothrombin G20210A mutation in cases with history of RM Material and methods A total of 104 cases 55 with diagnosis of RM and 49 control cases were included in this controlled study In all cases in addition to full examination tests Prothrombin 20210A mutation analysis was carried out by means of Polymerase Chain Reaction PCR Results Mean number of the abortion was 351±074 in the RM group and 008±027 in the control group p005 As a consequence of comprehensive examinations in 24 436 of 55 RM cases at least one etiologic factor was put forth Prothrombin G20210A mutation was observed in six 109 cases of the RM group and one 204 in the control group p005 Four of the six cases 667 of Prothrombin G20210A mutation had a subsequent pregnancy Among these four pregnancies there was one spontaneous loss at 14 weeks of gestation and one severe preeclampsia Conclusion Our data together with literature suggest that Prothrombin G20210A mutation may be associated with RM We recommend this genetic testing as a screening tool for women with history of RM

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