Authors: YanBo Du MinZhi Gao Yan Shi ZhaoGui Sun Jian Wang
Publish Date: 2012/10/04
Volume: 287, Issue: 1, Pages: 123-130
Abstract
A total of 65 follicular fluid aspirates were collected Concentrations of inflammatory factors IL1b PGE2 PGF2α and TGFβ2 and steroid hormones E2 progesterone FSH and LH within follicular fluid as well as serum E2 and LH concentrations were measured The mRNA expression of IL1b Ptgs2 aromatase and PPARγ in granulosa cells was determined The outcome of ART was monitored and recordedThe oocyte retrieval rate of metaphase II oocyte cleavage rate effective embryo rate and pregnancy rates of patients with endometriosis were all significantly lower than those of the control patients In those with endometriosis serum E2 concentrations were lower than those observed in controls Aromatase levels in the granulosa cells of the endometriosis group were lower while concentrations of PGE2 in follicular fluid were higher than in the control group Concentrations of PGE2 PGF2α TGFβ2 and IL1b were significantly correlated with each otherThese results suggest that the outcomes of ART in relation to serum E2 concentration were adversely affected by the presence of endometriosis Furthermore the results supported that among the endocrine and inflammatory factors PGE2 within the follicular fluid impairs the number and quality of oocytesWe certify that this work is our original unpublished work and it has not been submitted elsewhere for publication and we have full control of all primary date all authors have approved the manuscript to submit to your journal It is submitted with the full knowledge and approval of the institution or organization given as the affiliation of the authors No conflict of interest exists with this research
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