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Title of Journal: Arch Gynecol Obstet

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Abbravation: Archives of Gynecology and Obstetrics

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Springer Berlin Heidelberg

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DOI

10.1016/j.avdiab.2014.09.001

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ISSN

1432-0711

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Predictive value of pregnancyassociated plasma pr

Authors: Pietro Cignini Laura Maggio Savasta Ferdinando Antonio Gulino Salvatore Giovanni Vitale Lucia Mangiafico Alvaro Mesoraca Claudio Giorlandino
Publish Date: 2015/11/11
Volume: 293, Issue: 6, Pages: 1227-1233
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Abstract

Low levels of plasmatic pregnancyassociated plasma proteinA PAPPA and high levels of freebeta human chorionic gonadotropin betahCG could influence the outcome of pregnancy The objective of this study is to assess the correlation between PAPPA and free betahCG and birth weightProspective followup study performed on 3332 patients in the first trimester of pregnancy who were subjected to a screening test focused on evaluation of fetal aneuploidy SCATEST The values of PAPPA and free betahCG were both analyzed as raw values and subsequently converted to a multiple of the median MoM Statistical analysis was performed using SPSS version 1701 SPSS Inc Chicago USAThe incidence of “small for gestational age” in patients with PAPPA MoM 1st and 5th ‰ was statistically significant 12 and 98  p  00001 Also statistically significant data have been highlighted about free beta MoM  95th ‰ 7  p = 003 The values of PAPPA MoM  99th ‰ are significantly correlated with an increased risk of “large for gestational age” 167  p  00001The present article has been realized also thanks to the important scientific collaboration with Dr Francesca Romana Giorlandino Department of Biochemistry Altamedica Main Center Rome Italy and Dr Diana Giannarelli Department of Statistics National Cancer Institute Regina Elena Rome Italy

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