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Title of Journal: Arch Gynecol Obstet

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Abbravation: Archives of Gynecology and Obstetrics

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Springer Berlin Heidelberg

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DOI

10.1016/0963-8695(95)93706-c

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ISSN

1432-0711

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Association of −463G/A MPO gene polymorphism and r

Authors: Camilla Natter Stephan Polterauer Sophie Pils Dan Cacsire CastilloTong Robert Zeilinger Georg Heinze Lukas Hefler Christoph Grimm
Publish Date: 2015/08/29
Volume: 293, Issue: 4, Pages: 865-869
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Abstract

The MPO system plays an important role in the control of infections and the deletion of malignant cells Nevertheless alternations in the MPO system can lead to DNA damage and carcinogenesis Polymorphisms in the MPO Gene have been associated with an increased expression of MPO and a higher risk for development of cancer This study evaluates the association between −463G/A MPO gene polymorphism and the risk for CINThe MPO gene polymorphism −463G/A was investigated in 616 women with cervical intraepithelial neoplasia and in 206 healthy women Association between MPO gene polymorphism and risk of cervical intraepithelial neoplasia were analyzed by univariate and multivariable modelsNo significant difference in genotype distribution of the MPO gene polymorphism was observed in women with CIN and controls p = 04 OR 12 95  CI 08–16 A subgroup analysis only including women with CIN did not show an association between −463G/A MPO gene polymorphism and risk for highgrade CIN CIN 2/3 p = 009 OR 15 95  CI 09–23

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