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Title of Journal: Arch Gynecol Obstet

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Abbravation: Archives of Gynecology and Obstetrics

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Springer-Verlag

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DOI

10.1007/978-1-4020-5382-5_11

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1432-0711

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Malignant mixed Mullerian tumor of the ovary with

Authors: Berna Bozkurt Duman Ismail Oğuz Kara Meral Günaldi Vehbi Ercolak
Publish Date: 2011/02/06
Volume: 283, Issue: 6, Pages: 1363-1368
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Abstract

Malignant mixed Müllerian tumor MMMT of the ovary is a rare and highly aggressive tumor It accounts 1 of all ovarian carcinomas It is characterized by the presence of both carcinomatous and sarcomatous components and tends to occur in low parity postmenopausal woman These are mixed mostly monoclonal tumors and the predominance of the stromal component aggravates the prognosis The staging system for ovarian and primary peritoneal cancer is also used for MMMT After complete surgical staging patient with stage II–IV at the time of surgery should have postoperative chemotherapy Chemotherapy can be considered for stage I MMMT Its optimal treatment is debatable Taxane and platinum combination is standard for the epithelial ovarian carcinoma There is very limited literature reporting this combination therapy in ovarian MMMTsWe presented two cases of stage III primary ovarian MMMT The patients were treated with the taxane/platin combination without adverse events following surgery and remained in clinical remission in Case 1 at followup Case 2 has progressed after first line taxane/platin regimen and treated like epithelial ovarian carcinoma Case 1 was in complete remission in the followup visit 2 years later Case 2 died 14 months later after the tumor was initially diagnosed

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