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Title of Journal: Arch Gynecol Obstet

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Abbravation: Archives of Gynecology and Obstetrics

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Springer-Verlag

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DOI

10.1007/bf01058918

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ISSN

1432-0711

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Primary malignant melanoma of the cervix report o

Authors: Gülseren Yücesoy Evrim Kus Yigit Cakiroglu Bahar Muezzinoglu Kursat Yildiz Izzet Yucesoy
Publish Date: 2008/08/23
Volume: 279, Issue: 4, Pages: 573-575
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Abstract

The patient was admitted with the complaint of vaginal bleeding Gynecological examination revealed a dark papillary mass on the posterior lip of the cervix Histopathology showed a malignant neoplasm with increased vascularity indicating the possibility of a primary uterine cervical melanoma Diagnosis of malignant melanoma was confirmed with immunohistochemistry which showed diffuse positive reactions for S100 protein and HBM45 with no reaction for epithelial markers namely cytokeratin AE1/AE3 and epithelial membrane antigen An extensive search for a melanotic lesion in skin and in uveal tract was performed to verify the distinct site of melanoma The tumor was stage IB1 according to the International Federation of Gynecology and Obstetrics classificationThe patient underwent radical Wertheim–Meigs hysterectomy bilateral salpingooopherectomy and retroperitoneal pelvic lympadenectomy Radiotherapy or chemotherapy was not performed in the postoperative period She is now free of the disease 10 months after the operation

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