Authors: Banu Bingol Ziya Gunenc Murat Yilmaz Aydan Biri Bülent Tiras Haldun Güner
Publish Date: 2009/07/11
Volume: 281, Issue: 5, Pages: 857-864
Abstract
Forty women receiving and 38 women not receiving HRT were included and baseline and sixth month blood pressure weight body mass index waist/hip ratio blood lipid profile inflammatory markers homocysteine Creactive protein CRP and fibrinogen hemoglobin A1c HbA1c and insulin and oral glucose tolerance test OGTT results were evaluatedThe mean age was 526 ± 49 and 522 ± 50 years in the HRT and Control Groups respectively Whereas there was no change in the Controls the weight waist/hip ratio and BMI increased and diastolic blood pressure decreased in the HRT patients LDLc VLDLc and lipoprotein a levels were significantly higher in the HRT Group in the sixth month however total cholesterol and LDLc increased in the Controls but VLDLc and lipoprotein a did not CRP and homocysteine significantly increased and fibrinogen decreased whereas in the Control Group no significant change was detected A significant improvement in HbA1c and OGTT was found in both the groups whereas a significant reduction was measured only in the HRT GroupIn response to 6 months of HRT there was an increase in weight BMI and waist/hip ratio as known cardiovascular risk factors but no significant impact on lipid profile and glucose metabolism could have been clearly demonstrated A mixed effect profile of HRT on the state of inflammation increase in CRP and homocysteine decrease in fibrinogen was observed
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