Authors: Michelle G Discacciati Jose A Simoes Marcia G Silva Camila Marconi Eliane Brolazo Maria L Costa Jose G Cecatti
Publish Date: 2010/03/18
Volume: 283, Issue: 3, Pages: 501-508
Abstract
To evaluate vaginal microflora and interleukin1β ILβ interleukin6 IL6 interleukin8 IL8 and tumor necrosis factoralpha TNFα concentrations in the cervicovaginal fluid of a group of pregnant women in preterm labor when compared with a group of fullterm pregnant women not yet in laborCase–control study performed in a University tertiary referral maternity in Campinas Brazil with 45 pregnant women in preterm labor and 45 fullterm pregnant women not in labor All patients underwent speculum examination for the collection of cervicovaginal fluid Bacterial vaginosis BV was diagnosed according to the criteria of Amsel and Nugent Culture was performed for group B streptococcus GBS and lactobacilli and hybrid capture assay for screening for chlamydial and gonococcal infection Cytokine concentrations were measured using ELISA technique Statistical analysis was performed using χ2 Fisher’s exact and crude and adjusted odds ratios Significance level was defined at 5 The main outcome measures were cervicovaginal cytokines in preterm laborIL6 and IL8 were significantly associated with preterm labor The changes in vaginal microflora as well as BV and GBS were more frequent in women in preterm labor although BV and GBS showed no statistical significance The presence of Candida sp absence of lactobacilli positive screening for chlamydial and gonococcal infection and the presence of IL1β and TNFα were not associated with preterm labor
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