Authors: Mitra Niafar Leili Pourafkari Jahan Porhomayon Nader Nader
Publish Date: 2015/12/10
Volume: 293, Issue: 3, Pages: 509-515
Abstract
Seven RCTs where women with PCOS were treated with liraglutide were identified The variables that were examined before and after a 90day treatment included waist circumference body mass index BMI fasting insulin concentrations insulin resistance using homeostatic model HOMAIR serum testosterone and sex hormonebinding globulin SHBG The analysis included 178 women Only 172 patients had posttreatment measurements While BMI significantly dropped by −165 072–258 Kg/m2 after 3 months treatment with liraglutide waist circumference did not change significantly Similarly fasting insulin levels insulin sensitivity and SHBG did not change significantly However serum testosterone decreased by 029 nmol/L in 88 women P = 00003In a limited number of the women with PCOS BMI and serum testosterone are only variables that significantly decrease after 3 months of treatment with GLP1 receptor agonists Larger sample size studies with longer durations of treatment may be required to examine potential benefits of these medications in improving insulin sensitivity
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