Authors: Yonggang Zhang Qinling Ma Hongling Yang Yan Long Xingxing Liu Chen Zhou
Publish Date: 2015/05/19
Volume: 292, Issue: 5, Pages: 1043-1050
Abstract
A nested case–control study was performed at the Laboratory Department of Guangzhou Women and Children’s Medical Center From a prospective cohort of tens of thousands of unselected women with singleton pregnancies at 8–20 weeks gestation maternal plasma samples were obtained from 73 women who subsequently developed PIH PIH group and 146 gestational age and maternal agematched women with normotensive pregnancies control group Proteins extracted from the plasma samples were screened by microchip and verified by ELISA Clinical risk factor data were analyzed retrospectivelyCompared to the control group high concentrations of tissue inhibitor of metalloproteinase4 TIMP4 were found in women with PIH P = 0000 Univariate risk factor analysis identified three variables with significant differences between the groups family history of PIH P = 0031 body mass index BMI P 0001 and nonglucose6phosphate dehydrogenase deficiencyinduced anemia P 0027 Multiple regression analyses revealed a significant relationship of PIH with TIMP4 levels BMI and family history combined area under the receiver operating characteristic curve = 0820Upregulation of plasma TIMP4 might contribute to PIH processes Potential risk factors of this disease may include a family history of PIH and BMI The combination of TIMP4 levels and these risk factors may have some predictive values for PIH Future multicenter studies including greater numbers of samples analyzed proteins and risk factors are needed to obtain a higher predictive value of the model for the clinical diagnosis of PIH
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