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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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10.1007/bf02057779

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1432-1076

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Transient antiphospholipid antibodies associated w

Authors: H Mizumoto T Maihara E Hiejima M Shiota A Hata S Seto T Atsumi T Koike D Hata
Publish Date: 2006/03/22
Volume: 165, Issue: 7, Pages: 484-488
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Abstract

We describe two previously healthy children who had multiple ecchymoses several days after acute infection In both cases the prothrombin time PT and the activated partial thromboplastin time APTT were prolonged Further examinations revealed the presence of lupus anticoagulant LA phosphatidylserinedependent antiprothrombin antibodies aPS/PT and low serum complement In both cases we confirmed the presence of a serum immune complex The patients’ symptoms improved spontaneously within 1 week and all laboratory data normalized within several months We also describe another asymptomatic case positive for LA and aPS/PT presumably associated with cytomegalovirus infection The prevalence of transient antiphospholipid antibodies associated with viral infections in children must be much higher than we expected We have to take it into consideration when we see abnormal coagulation results but the occurrence of significant bleeding symptoms is rare

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