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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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DOI

10.1007/bf01295602

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1432-1076

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Clustering of autoimmune diseases with earlyons

Authors: Mirjam Bueno de Mesquita Marc Ferrante Liesbet Henckaerts Marie Joossens Virginie Janssens Tibor Hlavaty Marie Pierik Sofie Joossens Nele Van Schuerbeek Gert Van Assche Paul Rutgeerts Severine Vermeire Ilse Hoffman
Publish Date: 2008/08/01
Volume: 168, Issue: 5, Pages: 575-583
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Abstract

Studies in adult inflammatory bowel disease IBD patients have highlighted associations with genetic and serologic markers and suggest an association with disease location behaviour and natural history Data on patients with Crohn’s disease CD n = 80 ulcerative colitis UC n = 15 and indeterminate colitis n = 4 were collected All individuals were analysed for CARD15 R702W G908R and L1007fs for tolllike receptor 4 TLR4 Asp299Gly and for antiSaccharomyces cerevisiae antibodies ASCA and atypical perinuclear antineutrophil cytoplasmatic antibodies pANCA After a mean of 107 years of follow up the disease behaviour changed in 45 of CD patients in contrast to disease location where only 125 had a change p  0001 The younger the age at diagnosis the more patients presented with colonic disease p = 0021 Also more TLR4 Asp299 Gly variants were found when the age at onset was younger p = 0018 A large number of concomitant diseases were observed There was no difference in the prevalence of TLR4 variants nor ASCA or pANCA between the patients with or without concomitant diseases Patients who progressed more often needed surgery as compared to patients who remained free of stenosing or fistulising disease 27/32 or 84 versus 3/35 or 86 respectively p  00001 and more often had concomitant immunemediated diseases and a trend for more seroreactivity towards ASCA

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