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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer Berlin Heidelberg

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1432-1076

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MagicplexSuperscriptTM/Superscript Sepsis Real

Authors: Denina Marco Scolfaro Carlo Colombo Sara Calitri Carmelina Garazzino Silvia Barbui Anna Maria Brossa Silvia Regina Margherita Children’s Hospital Bloodstream Infections Study Group participants Tovo PierAngelo
Publish Date: 2016/06/29
Volume: 175, Issue: 8, Pages: 1107-1111
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Abstract

Sepsis is the major cause of morbidity and mortality in children especially in immunocompromised patients and a rapid identification of causative pathogen is strongly related with a better outcome This prospective study analyzes the role of a multiplex realtime polymerase chain reaction in sepsis’ etiological diagnosis MagicplexTM Sepsis RealTime tests were performed in tertiary Regina Margherita Children’s Hospital Turin Italy and the medical records of children who underwent a Magicplex test were prospectively evaluated Results of the Magicplex test were compared with those of blood culture collected at a close time point One hundred fifty Magicplex tests were collected from 89 patients 54 males and 35 females age interquartile range 26–121 years Etiological definition was achieved in 60 bloodstream infection cases 40  In 32 episodes Magicplex test alone gave a positive result and blood culture alone permitted the etiological diagnosis in 5 septic episodes Magicplex test allowed a 143  increase in the diagnostic value of blood cultures

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