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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer Berlin Heidelberg

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1432-1076

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Risk factors for ventilatorassociated pneumonia i

Authors: Bin Tan Fan Zhang Xian Zhang YaLing Huang YuShuang Gao Xiao Liu YingLi Li JingFu Qiu
Publish Date: 2014/02/13
Volume: 173, Issue: 4, Pages: 427-434
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Abstract

Ventilatorassociated pneumonia VAP is a common and serious problem among mechanically ventilated patients in intensive care units ICU especially for the newborn However limited literatures have been reviewed to synthesize the finding of previous papers to investigate the risk factors for VAP although it has been a serious complication of mechanical ventilation MV with a high morbidity and mortality in the newborn We performed this metaanalysis to extend previous knowledge for developing VAP prevention strategies by identifying the potential risk factors related to VAP in the neonatal intensive care unit NICU The relevant literatures published up to July 2013 were searched in the databases of PubMed Cochrane Central Register of Controlled Trials Embase and Web of Science Three reviewers screened those literatures and extracted data according to the inclusion and exclusion criteria independently A total of eight studies including 370 cases and 1071 controls were identified Ten risk factors were found to be related to neonatal VAP which were listed as follows in order by odds ratios ORs length of stay in NICU OR 2345 reintubation OR 918 enteral feeding OR 559 mechanical ventilation OR 404 transfusion OR 332 low birth weight OR 316 premature infants OR 266 parenteral nutrition OR 230 bronchopulmonary dysplasia OR 221 and tracheal intubation OR 112 Conclusion We identified ten variables as independent risk factors for the development of VAP length of stay in NICU reintubation enteral feeding mechanical ventilation transfusion low birth weight premature infants parenteral nutrition bronchopulmonary dysplasia and tracheal intubation Due to several limitations in the present study further large and welldesigned studies are needed to confirm the conclusion

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